A large number of cellular proteins bind ATP, frequently utilizing the free energy of ATP hydrolysis to drive specific biological reactions. Recently, a family of closely related ATP‐binding proteins has been identified, the members of which share considerable sequence identity. These proteins, from both prokaryotic and eukaryotic sources, presumably had a common evolutionary origin and include the product of the white locus of Drosophila, the P‐glycoprotein which confers multidrug resistance on mammalian tumours, and prokaryotic proteins associated with such diverse processes (...) as membrane transport, cell division, nodulation and DNA repair. A comparison of these various proteins provides valuable insights into the function and evolution of the multicomponent systems with which they are associated. (shrink)

This essay deals with property rights in body parts that can be exchanged in a market. The inquiry arises in the following context. With some exceptions, the laws of many countries permit only the donation, not the sale, of body parts. Yet for some years there has existed a shortage of body parts for transplantation and other medical uses. It might then appear that if more sales were legally permitted, the supply of body parts would increase, because people would have (...) more incentive to sell than they currently have to donate. To allow sales is to recognize property rights in body parts. To allow sales, however, makes body parts into “commodities”—that is, things that can be bought and sold in a market. And some view it as morally objectionable to treat body parts as commodities. (shrink)

In this foundational work on the theory of linguistic and mental representation, Stephen Schiffer surveys all the leading theories of meaning and content in the philosophy of language and finds them lacking. He concludes that there can be no correct, positive philosophical theory or linguistic or mental representation and, accordingly advocates the deflationary "no-theory theory of meaning and content." Along the way he takes up functionalism, the nature of propositions and their suitability as contents, the language of thought and (...) other sententialist theories of belief, intention based semantics, and related issues in ontology. Stephen Schiffer is Professor of Philosophy at the City University of New York Graduate Center. A Bradford Book. (shrink)

Dennett's Consciousness Explained presents, but does not demonstrate, a fully naturalized account of consciousness that manages to leave out the very consciousness he purports to explain. If he were correct, realism and methodological individualism would collapse, as would the very enterprise of giving reasons. The metaphors he deploys actually testify to the power of metaphoric imagination that can no more be identified with the metaphors it creates than minds can be identified with memes. That latter equation, of minds with meme?complexes, (...) rests for its meaning on the existence of real minds, which are not to be equated with the thoughts they have. (shrink)

Illness has a way of disorientating us, as if we are cast adrift in a foreign land. Like strangers in a dessert we seek oasis to recollect ourselves, find refuge and learn to build our own shelters. Using the philosophy of Levinas and Derrida, we can interpret health care providers (HCP), and the sites from which they act (e.g. hospitals), as _dwelling hosts_ that offer hospitality to strangers in this foreign land. While often the dwellings are physical (e.g. hospitals), this (...) is not always the case. Language represents a mobile home of refuge to the sick. Using language the HCP has built a shelter so as to dwell in the land of illness. However, while hospitality is an inviting concept, it also implies hostility. The door that opens may also be slammed shut. This article explores the paradox of the linguistic mobile home offered to patients. It highlights the power of language to construct a safe place in a strange land, but also explores the inherent violence. It ends with an exploration of the ways language can be used by HCP to assist patients to construct their own mobile shelters. (shrink)

In this chapter, Immanuel Kant turns his attention back to the theme that was his earlier focus: the biblical scholars who tend to obscure the natural religion that lies at the heart of Jesus’ teaching. First, he argues that viewing unphilosophical clergy as spiritual guides is bound to promote delusory ways of being religious. Then, Kant claims that true service of God must be guided not by clergy but by conscience. According to Kant, the church leaders portray their preferred tradition (...) in a way that enables them to control people toward nonmoral ends. He states the same basic point in terms of the distinction between virtue and “godliness”. Properly interpreting the latter term, holds the key to unlocking the mystery of how religion can serve as a path to realizing the former, universal human duty. Yet misinterpreting this same term leads straight to idolatry. (shrink)

"In this engaging study Professor Clark sets out to show that there are good philosophical reasons for theism, and Christian theism in particular. He travels the breadth of our intellectual engagement with the world, from ethics to scientific knowledge, and his journey is vigorously argued, fresh, lively and readable. He explores the assumptions which underpin our philosophical and everyday thinking alike, examines the construction of the arguments used to support them, and tests the sturdiness and the makeup of their props (...) and foundations." --Cover. (shrink)

Averroes on Intellect provides a detailed analysis of the Muslim philosopher Averroes 's notorious unicity thesis -- the view that there is only one separate and eternal intellect for all human beings. It focuses directly on Averroes' arguments, both from the text of Aristotle's De Anima and, more importantly, his own philosophical arguments in the Long Commentary on the De Anima. Stephen Ogden defends Averroes' interpretation of De Anima using a combination of Greek, Arabic, Latin, and contemporary sources. Yet, (...) Ogden also insists that Averroes is not merely a 'commentator' but an incisive philosopher in his own right. The author thus reconstructs and analyzes Averroes' two most significant independent philosophical arguments, the Determinate Particular Argument and the Unity Argument. Alternative ancient and medieval views are also considered throughout, especially from two important foils before and after Averroes, namely, Avicenna and Thomas Aquinas. Aquinas' most famous and penetrating arguments against the unicity thesis are also addressed. Finally, Ogden considers Averroes' own objections to broader metaphysical views of the soul like Avicenna's and Aquinas', which agree with him on several key points including the immateriality of the intellect and the individuation of human souls by matter, while still diverging on the number and substantial nature of the intellect. The central goal of this book is to provide readers with a single study of Averroes' most pivotal arguments on intellect, consolidating and building on recent scholarship and offering a comprehensive case for his unicity thesis in the wider context of Aristotelian epistemology and metaphysics. (shrink)

Reply to a commentary by Timothy F. Murphy.

‘What does the brain have to do with learning?’Prima facie, this may seem like a strange thing for anyone to say, especially educational scholars, researchers, practitioners, and policy makers. There are, however, valid objections to injecting various and sundry neuroscientific considerations piecemeal into the vast field of education. These objections exist in a variety of dimensions. After providing a working definition for educational neuroscience, identifying the ‘mindbrain’ as the proper object of study thereof, I discuss, dispel or dismiss some of (...) these objections prior to presenting my motivations, aims, and prospects for this new area of educational research. I then briefly outline a positive case for educational neuroscience in terms of theories, methods, and collaborations, and conclude with a brief discussion of some challenges, results, and implications thereof. Naturally, the following considerations are but my own, some of which may be shared to some extent by others working in this area, as the case may be. (shrink)

This paper defends a simple and surprisingly adequate definition of philosophy: as suggested by the “know thyself” imperative, philosophy is the “self-defining” discipline. The task of philosophizing is therefore best described as the task of self-defining. In responding to various objections, I defend four senses in which this definition holds. First, when other academic disciplines seek to define the nature of their discipline, they are generally recognized as exploring the philosophy of their discipline; only for philosophy is such an inquiry (...) self-referential, remaining fully within the discipline itself. Second, while some genuinely philosophical topics do not explicitly involve self-defining, philosophy as a way of life always has self-examination at its core. Third, even though psychology may have largely usurped philosophy’s classical role as the guardian of self-knowledge, the goal of helping persons to refine their own self-understanding is still crucial for philosophers today. Finally, in a deep but paradoxical sense, genuine philosophy is self-authenticating. While Socrates’ maxim, “the unexamined life is not worth living” should not be taken too literally, it does correctly convey the fact that only an authentic life is really worth living. (shrink)

The principle that is, for Plotinus, both origin and goal of all things is labelled, for convenience, the One, or—equivalently—the Good. Plotinus is clear that even these titles may be misleading, since this principle is not one thing among many, nor can we even truly say that it exists. Nothing that we can say of it is really true, and we cannot ever strictly know or understand it. It must seem to follow that, having nothing true to say of it, (...) nor any way of grasping its nature, we had better simply be silent, as Plotinus agrees. This does not stop him from continuing... (shrink)

Bosnian translation of "How 'Chinese' Was Kant?" (abridged version).

Journal of Chinese Philosophy, EarlyView.

The prelims comprise: Introduction The Range of Genetic Material Nonhuman Genetic Material and Life Forms Nonconsequentialist Arguments against Property Rights in Human Genetic Material Conclusion.

A study of Plotinus's use of myth and metaphor, with special attention to the historical context and therapeutic use of his work.

There is both theoretical and experimental reason to suppose that no-one could ever have learned to speak without an environment of language-users. How then did the first language-users learn? Animal communication systems provide no help, since human languages aren't constituted as a natural system of signs, and are essentially recursive and syntactic. Such languages aren't demanded by evolution, since most creatures, even intelligent creatures, manage very well without them. I propose that representations, and even public representations like sculptures, precede full (...) languages, which were devised by the first human children as secret tongues to create fantasy realms inaccessible to their proto-human parents. Language, in brief, is not required for truth-telling or for the convenience of hunters. It is a peculiar modification of public representation, which permits us to construct new public worlds. (shrink)

Despite the recent claims of some prominent Catholic philosophers, I argue that Cardinal Newman's writings are in fact largely compatible with the contemporary movement in the philosophy of religion known as Reformed Epistemology, and in particular with the work of Alvin Plantinga. I first show how the thought of both Newman and Plantinga was molded in response to the "evidentialist" claims of John Locke. I then examine the details of Newman's response, especially as seen in his Essay in Aid of (...) A Grammar of Assent, suggesting that many of Newman's central ideas closely mirror Plantinga's. Finally, I argue that ifNewman and Plantinga part ways at any point, it is with respect to the basicality of specifically Christian (as opposed to theistic) belief. (shrink)

These two companion volumes provide a comprehensive review and critical evaluation of the major DSM-III and DSM-III-R child disorders. Their major goal is to provide diagnostic and assessment guidelines that are based on scientific literature in specific clinical domains. Each chapter contains a discussion of the historical background of a particular diagnosis, definitional issues, a critical but selective review of the literature addressing the diagnosis in question, proposed changes in the diagnostic criteria based on the available literature, and proposed assessment (...) models and methods based on the designated criteria. Given the scientific bases for many of these discussions of diagnostic criteria, these two volumes will serve professionals and graduate students in a wide variety of fields: clinical child psychology, child psychiatry, pediatrics, pediatric and school psychology, special education, social work, and other child mental health specialties. (shrink)

Twenty years ago, people thought only cranks or sentimentalists could be seriously concerned about the treatment of non-human animals. However, since then philosophers, scientists and welfarists have raised public awareness of the issue; and they have begun to lay the foundations for an enormous change in human practice. This book is a record of the development of 'animal rights' through the eyes of one highly-respected and well-known thinker. This book brings together for the first time Stephen R.L. Clark's major (...) essays in one volume. Written with characteristic clarity and persuasion, Animals and Their Moral Standing will be essential reading for both philosophers and scientists, as well as the general reader concerned by the debates over animal rights and treatment. (shrink)

The victory of Ellerman's technetronic civilization is indeed a fearful prospect, but one that is much less plausible than he allows. His imagined makers, as was pointed out forty odd years ago by C. S. Lewis, could themselves have no criterion of right action or right belief, nor could they sensibly expect ? either on secular or on thcistic suppositions ? to be able to control the world forever.

This chapter reviews classical accounts of natural theology. These include accounts by Hesiod of Boeotia in the late 8th century BC, Parmenides of Elea, Empedocles of Acragas, Aristotle, Plato, and the Roman senator Boethius.

Jonathan Edwards identified the central act of faith as ‘the cordial consent of beings to Being in general’, which is to say to God. That equation, of Being, Truth and God, is rarely taken seriously in analytical circles. My argument will be that this is to neglect the real context of a great deal of past philosophy, particularly the very Cartesian arguments from which so many undergraduate courses begin. All too many students issue from such courses immunized against enthusiasm, in (...) the conceit that they have answers to all the old conundrums, which were in any case no more than verbal trickery. ‘By uttering the right words but failing to use them in propria persona, philosophy induces a kind of soporific amnesia bewitching us into forgetting our God-given task. That task is, of course, to do what Socrates did and to live as he lived'. Burrell's words are not wholly fair to academic philosophers, nor to the Lady Philosophy. Plenty of philosophers really mind about the truth, and want to be Socratic in pursuit of it. But the danger is a real one. If all that matters is debunking past philosophers, how does that differ from the repeated refutation of the Chaldaean Oracles or the Prophecies of Nostradamus? A pretty enough pastime for the young, but hardly serious business for adults. ‘If the history of philosophy is a process of ‘salvaging’ what you yourself have already thought, then why bother?’. (shrink)

In this book, Stephen R.L. Clark defends the primary faith of humankind, that there is a real world which is more than a shadow of our desires and fancies, and which can be discovered through right reason. Focusing on the way in which we can "turn aside" to the Truth from the normal delusions of self-concern, Clark offers a properly worked, Platonic metaphysics as the key to identifying that reality. This book is the final volume of Limits and Renewals, (...) a trilogy based on the author's Stanton lectures, delivered at Cambridge between 1986 and 1989, and his Wilde lectures, delivered at Oxford in 1990. (shrink)

In this chapter, Immanuel Kant explains the crucial role played by biblical scholars: true religion must be universal, yet the dogmas that define a historical faith are not naturally universal. He attempts to defend the role of biblical scholars as both necessary and legitimate. Kant then turns to an analysis of why biblical theologians nevertheless tend to have a negative effect on church life and why the traditional linkage between Christianity and Judaism only exacerbates this problem. He relates both the (...) “convoy” metaphor and his redefinition of faith, as grounded in one of two possible principles, to his earlier distinction between true service and pseudoservice. Kant also explores different aspects of how churches tend to be unsuccessful in such efforts and how such failures can be avoided. The chapter concludes with comments on a more affirmative topic, where Kant conveys a principle to assist visible churches in avoiding religious delusion. (shrink)

I consider reasons for questioning ‘the laws of logic’, and suggest that these laws do not accord with everyday reality. Either they are rhetorical tools rather than absolute truths, or else Plato and his successors were right to think that they identify a reality distinct from the ordinary world of experience, and also from the ultimate source of reality.

How the 'Aristotelian' biological synthesis has been affected by modern accounts of biological evolution, and the relation of taxonomy to ethics.

These are hard days for globalism. A major candidate for the United States presidency ran on an anti-immigration, anti-free-trade platform and denounced such venerable international institutions as the North Atlantic Treaty Organization and the United Nations. The European Union is under threat after the vote for Brexit; the Euro is under strain. China is denouncing and ignoring the result of an international arbitration over its claims to the South China Sea. Nationalist, xenophobic political parties are in the ascendency around the (...) world, buoyed by the fears and pains of populations for whom global trade has been no boon and to whom waves of new immigrants seem threatening both economically and socially. So it is both strange and uplifting, in this atmosphere, to encounter the ambitious and enthusiastic globalism of Lawrence Gostin's important, field-founding work, Global Health Law. Equal parts encyclopedia and manifesto, the book seeks both to provide exhaustive and up-to-date descriptions of the already-substantial body of international health law and of its implementing institutions and to chart Gostin's vision for their vigorous expansion. And that vision is nothing if not expansive. (shrink)

Words have determinable sense only within a complex of unstated assumptions, and all interpretation must therefore go beyond the given material. This book addresses what is man's place in the Aristotelian world. It also describes man's abilities and prospects in managing his life, and considers how far Aristotle's treatment of time and history licenses the sort of dynamic interpretation of his doctrines that have been given. The ontological model that explains much of Aristotle's conclusions and methods is one of life-worlds, (...) in which the material universe of scientific myth is no more than an abstraction from lived reality, not its transcendent ground. (shrink)

Kant and Mysticism interprets Kant’s early criticism of Swedenborg’s mysticism as the fountainhead of the Critical philosophy. Kantian Critique revolutionizes not only traditional metaphysics, but also our understanding of mysticism: Critical mysticism is a unitive experience that impels us to lay bare all human pretensions to reason’s light.